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KMID : 1144120220120020147
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Biomedical Engineering Letters
2022 Volume.12 No. 2 p.147 ~ p.153
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Performance comparison of high-speed photoacoustic microscopy: opto-ultrasound combiner versus ring-shaped ultrasound transducer
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Kim Hyo-Jin
Kim Jin-Young
Cho Seong-Hee
Ahn Joong-Ho
Kim Yeong-Geun
Kim Hyung-Ham
Kim Chul-Hong
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Abstract
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Photoacoustic microscopy (PAM) embedded with a 532 nm pulse laser is widely used to visualize the microvascular structures in both small animals and humans in vivo. An opto-ultrasound combiner (OUC) is often utilized in high-speed PAM to confocally align the optical and acoustic beams to improve the system's sensitivity. However, acoustic impedance mismatch in the OUC results in little improvement in the sensitivity. Alternatively, a ring-shaped ultrasound transducer (RUT) can also accomplish the confocal configuration. Here, we compare the performance of OUC and RUT modules through ultrasound pulse-echo tests and PA imaging experiments. The signal-to-noise ratios (SNRs) of the RUT-based system were 15 dB, 12 dB, and 7 dB higher when compared to the OUC-based system for ultrasound pulse-echo test, PA phantom imaging test, and PA in-vivo imaging test, respectively. In addition, the RUT-based system could image the microvascular structures of small parts of a mouse body in a few seconds with minimal loss in SNR. Thus, with increased sensitivity, improved image details, and fast image acquisition, we believe the RUT-based systems could play a significant role in the design of future fast-PAM systems.
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KEYWORD
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Performance comparison, Photoacoustic microscopy, Opto-ultrasound combiner, Ring-shaped ultrasound transducer, Sensitivity, Signal-to-noise ratio
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